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In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care. HIV medications were ineffective in a trial of 200 patients. -NEJM March 2020
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Moderna announces early results of it's vaccine using mRNA. Phase 3 study with 30,000 patients. 90 in placebo arm developed covid while only 5 in the mRNA group indicating a 94.5% vaccine efficacy. Link to Moderna PDF.
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Vanderbilt University in Nashville, Tennessee, is starting a hydroxychloroquine study of 15,000 healthcare workers to see if it will prevent covid-19 infection. It is called the HERO-HCQ study.
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Texas
#coronavirus cases map by county
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Red Cross has started to accept plasma from patients who have recovered from coronavirus to donate to patients with severe infections. This will be part of a research study.
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April 1, 2020 - Mount Sinai in New York City has started a research study of transfusing plasma from donors who have recovered from coronavirus 21 days prior. Thousands have volunteered to donate plasma.
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For adults receiving mechanical ventilation who have acute respiratory distress syndrome (ARDS), use of low tidal volume ventilation (4-8 mL/kg of predicted body weight) is recommended and preferred over higher tidal volumes (>8 mL/kg)
#coronavirus -JAMA March 26, 2020
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Remdesivir is being evaluated in a trial of 1600 patients over multiple sites. Early data of 150 severe patients from University of Chicago are promising with several being discharged home. The drug is made by Gilead.
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Florida coronavirus cases county by county interactive map.
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The virus attaches to angiotensin converting enzyme (ACE2) protein on human cells. It could have originated from bats or pangolins. -Genomic Study Points to Natural Origin of COVID-19
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Five patients on mechanical ventilation improved after receiving plasma from people who recovered from
#coronavirus. -JAMA March 27, 2020
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The virus spread through all of China in 30 days. "overall case-fatality rate (CFR) was 2.3% (1023 deaths among 44 672 confirmed cases). No deaths occurred in the group aged 9 years and younger, but cases in those aged 70 to 79 years had an 8.0% CFR and cases in those aged 80 years and older had a 14.8% CFR"
#coronavirus JAMA 2020
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Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China " 3.6% asymptomatic SARS-CoV-2 infection might take a turn for the worse" - March 2020 Journal of Infectious Disease
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